DEPARTMENT OF MOLECULAR BIOPHYSICS

The Head of the Department: Aneta Balcerczyk, Ph.D., D.Sc.

Address: 141/143 Pomorska St., 90-236 Lodz, building D, room Bfi9
Tel: +48 42 635 44 76
Fax: +48 42 635 45 10
e-mail:

 

Secretary unit: Beata Sudak, M.Sc.

Address: 141/143 Pomorska St., 90-236 Lodz, building D, room Bfi53
Tel: +48 42 635 45 10
Fax: +48 42 635 45 10
e-mail:

 

Cytometry Laboratory (head: Błażej Rychlik, Ph.D.)

BioBank Laboratory (head: Dominik Strapagiel, Ph.D.)

 

 

Staff of Department of Molecular Biophisics:

Name Phone e-mail Building/
Room
Consultations

Aneta Balcerczyk, Ph.D., D.Sc.
(The Head of the Department)

+48 42
635 44 76
D/Bfi-9  

Prof. dr hab. Krzysztof Gwoździński

+48 42
635 44 52
D/Bfi-49  

Prof. dr hab. Mirosław Soszyński

+48 42
635 45 10
D/Bfi-52  

Łukasz Pułaski, Ph.D., D.Sc., Associate Professor

+48 42
665 57 02
D/Bfi-51-52  

Anna Pieniążek, Ph.D., D.Sc., Lecturer

+48 42
635 44 10

D/Bfi-48,
Bfi-16
 

Aleksandra Rodacka, Ph.D., D.Sc., Lecturer

+48 42
635 44 57
D/Bfi-10  

Joanna Bernasińska-Słomczewska, Ph.D., Lecturer

+48 42
635 44 10
D/Bfi-48,
Bfi-16
 

Joanna Brzeszczyńska, Ph.D., Lecturer

  D/Bfi-48,
Bfi-16
 

Jan Czepas, Ph.D., Lecturer

+48 42
635 44 80

D/Bfi-48,
Bfi-16
 

Jacek Grębowski, Ph.D., Lecturer

+48 42
635 44 80

D/Bfi-50  

Paweł Hikisz, Ph.D., Lecturer

+48 42
635 44 10

D/Bfi-48,
Bfi-16
 

Katarzyna Nowak, Ph.D., Lecturer

+48 42
635 44 57

D/Bfi-10  

 

Ph.D. student:

Imię i nazwisko Telefon e-mail Budynek/
pokój
Konsultacje

M.Sc. Marta Besiekierska

+48 42
635 45 10/p>
D/Bfi-51–52  

M.Sc. Oskar Ciesielski

+48 42
665 45 10

D/Bfi-51-52  

M.Sc. Dominika Komorowska

+48 42 635 44 05

D/Bfi-11/12  

M.Sc. Anna Lichota

+48 42 635 44 05

D/Bfi-11/12  

M.Sc. Joanna Strumiłło

+48 42
635 44 05

D/Bfi-11/12  

M.Sc. Maciej Studzian

+48 42
665 50 74

A/5.23–5.35  

M.Sc. Martyna Wojtala

+48 42
635 45 10

D/Bfi-51-52  

M.Sc. Varvara Vialichka

+48 42
635 45 10

D/Bfi-51-52  

 

Research topics of the Department of Molecular Biophysics

  1. Epigenetic regulation of vascular endothelial cell function conditioned by post-translational modifications of histone proteins.
  2. The effect of the ketogenic diet and beta-hydroxybutyrate on key histone code signatures. Analysis of their potential values in metabolic disorders.
  3. The role of small molecules of plant origin in the prevention of neuronal cell death induced by oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
  4. Assessment of the potential of plant origin compounds in sensitizing breast cancer cells to ionizing radiation action.
  5. Investigation of changes induced by anticancer drugs in the organs of rats and in normal and cancer cell lines. Elimination of these effects by synthetic (nitroxides) and natural (flavonoids) antioxidants.
  6. Evaluation of the blood cells damage induced by uremic toxins.
  7. Investigations of stem cells and organ regeneration processes to develop new diagnostic and therapeutic strategies.
  8. Investigations of the oxidative stress parameters in the blood cells of patients with chronic kidney and venous diseases and patients after cardiological incidents.
  9. Mechanisms of erythrocytes damage by selected reactive oxygen species. Oxidative damage and modification of proteins and their prevention. Mechanisms of antioxidant activity.
  10. Study of the water purity in lakes located in Bory Tucholskie and oxidative stress parameters in selected aquatic organisms.
  11. Study of the properties of the active compounds molecules and their interactions with biomolecules.
  12. Application of confocal microscopy (including fluorescence lifetime imaging) in cell biology, membrane function and taxonomy; molecular genetics and cellular signalling in pharmacokinetics and toxicology.
  13. The influence of metallofulerenols on radical processes taking place in model biological membranes.

 

Research projects carried out by the Department of Molecular Biophysics (last 3 years)

  1. 2019–2022, HARMONIA National Science Centre, Poland, 2019/30/M/NZ3/00682 – “Nutrition, Epigenetics and Disease – Effect of the ketogenic diet and beta-hydroxybutyrate on key histone code signatures. Analysis of their potential values in metabolic disorders” – Principal Investigator – A/Prof. Aneta Balcerczyk, Department of Molecular Biophysics, University of Lodz.
  2. 2020–2021, Grant of the National Agency for Academic Exchange (NAWA) as part of the Polish-French bilateral exchange program – POLONIUM. “Analysis of epigenetic mechanisms regulating the ketogenesis process” Partner: A/Prof. Luciano Pirola (INSERM U1060, Lyon, France).
  3. 2019-2022, Grant MRSEI „RISE UP” ANR n 19-MNR1-0012-01 as a part of the Horizon 2020. Partners: A/Prof. Luciano Pirola (INSERM U1060, Lyon, France) i A/Prof. Maura Strigini (INSERM U1059, Lyon, France).
  4. 2019–2023, diamond grant Ministry of Science and Higher Education, Poland, DI2018 018948 – “Analysis of the epigenetic profile of modification of selected arginines of core histones and their consequences for other post-translational modifications and the functioning of the vascular endothelium” – Principal Investigator - M.Sc. Oskar Ciesielski, Department of Molecular Biophysics, University of Lodz.
  5. 2017–2020, PRELUDIUM, National Science Centre, Poland, 2016/23/N/NZ3/02435 – “The role of lysine-specific demethylase 1 in the regulation of the inflammatory response of vascular endothelial cells” - Principal Investigator – M.Sc. Martyna Wojtala, Department of Molecular Biophysics, University of Lodz.
  6. 2020–2023, SONATA, NCN 2019/35/D/ST4/02627 – “Metallofullerenols as a new generation of radioprotective agents – in vitro studies of radical processes in model biological membranes and in cellular model under radiation-induced oxidative stress” – Principal Investigator – Ph.D. Jacek Grebowski, Department of Molecular Biophysics, University of Lodz.
  7. 2018–2019, PRELUDIUM, National Science Centre, Poland, 2017/25/N/NZ1/02849 – “Evaluation of neuroprotective properties of piceatannol in model biological systems” - Principal Investigator – M.Sc. Joanna Gerszon, Department of Molecular Biophysics, University of Lodz.
  8. 2019–2023, OPUS, National Science Centre, Poland, 2019/17/B/NZ9/ – “Biological activity of extracts from selected species of fermentation (Rheum L.) – research on the properties of the raw material in terms of the assessment of cardioprotective potential” – Principal Investigator, A/Prof. Joanna Kołodziejczyk-Czepas, Department of General Biochemistry, University of Lodz.
  9. 2019–2021, M-ERA.Net Call 2018 – NanoTENDO – “Nanoparticle Transfer Through Endothelial Barrier” – Principal Investigator, Prof. Maria Bryszewska, Department of General Biophysics, University of Lodz.
  10. 2018–2020, OPUS, National Science Centre, Poland, 2015/17/B/NZ7/03019 – “The role of epigenetic changes and p53 in visceral adipose tissue and the pathogenesis of type 2 diabetes” – Principal Investigator, Prof. Janusz Szemraj, Department of Medical Biochemistry, Medical University in Lodz.

 

Publications (last 3 years):

2020

  1. Nasser S, Vialichka B, Biesiekierska M, Balcerczyk A, Pirola L. The effects of ketogenic diet and ketone bodies on the cardiovascular system. Concentration matters. World Journal of Diabetes, 2020, (praca przyjęta do druku)
  2. Balcerczyk A, Damblon C, Elena-Herrmann B, Panthu B, Rautureau G. Metabolomic approaches to study chemical exposure-related metabolism alterations in mammalian cell cultures. International Journal of Molecular Sciences, 2020, 21, 6843; doi: 10.3390/ijms21186843
  3. Ciesielski O, Biesiekierska M, Balcerczyk A. Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells. Molecules, 2020, 25(10), E2326.
  4. Woźniak E, Reszka E, Jabłońska E, Mokra K, Balcerczyk A, Huras B, Zakrzewski J, Bukowska B. The selected epigenetic effects of aminomethylphosphonic acid, a primary metabolite of glyphosate on human peripheral blood mononuclear cells (in vitro). Toxicology in vitro, 2020, 66, 104878.
  5. Ciesielski O, Biesiekierska M, Panthu B, Vialichka V, Pirola L, Balcerczyk A. The epigenetic profile of tumor endothelial cells. Effects of combined therapy with antiangiogenic and epigenetic drugs on cancer progression. International Journal of Molecular Sciences, 2020, 21(7), E2606.
  6. Dąbek A, Wojtala M, Pirola L, Balcerczyk A. Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states. Nutrients, 2020, 12(3), E788.
  7. Woźniak E, Reszka E, Jabłońska E, Balcerczyk A, Broncel M, Bukowska B. Glyphosate affects methylation in the promoter regions of selected tumor suppressors as well as expression of major cell cycle and apoptosis drivers in PBMCs (in vitro study). Toxicology in Vitro, 2020, 63, 104736. doi: 10.1016/j.tiv.2019.104736
  8. Pieniazek A, Szczepocki A. Structural component changes of erythrocytes caused by oxidative stress generated by indoxyl sulfate. Toxicol in Vitro 2020. doi.org/10.1016/j.tiv.2020.105013 (in press)
  9. Lichota A, Gwozdzinski K, Szewczyk E. Microbial Modulation of Coagulation Disorders in Venous Thromboembolism. J Inflamm Res. 2020, 13, 387–400. doi: 10.2147/JIR.S258839
  10. Morgan K, Bryans A, Brzeszczyński F, Samuel K, Treskes P, Brzeszczyńska J, Morley S, Nelson, Hayes P. Oxygen plasma-treated substrates and specific nanopattern promote early differentiation and function of HepaRG progenitor cells. Tissue Eng Part A. 2020. doi: 10.1089/ten.TEA.2019.0241 (in press)
  11. Brzeszczyńska J, Brzeszczyński F, Samuel K, Morgan K, Morley SD, Plevris JN, Hayes PC. Validation of reference genes for gene expression studies by RT-qPCR in HepaRG cells during toxicity testing and disease modelling. Cells, 2020, 9(3), 770. doi: 10.3390/cells9030770
  12. Żabka A, Winnicki K, Polit JT, Bernasinska-Slomczewska J, Maszewski J. 5-Aminouracil and other inhibitors of DNA replication induce biphasic interphase–mitotic cells in apical root meristems of Allium cepa. Plant Cell Reports, 2020, 39(8), 1013–1028. doi: 10.1007/s00299-020-02545-9
  13. Adamus-Grabicka AA, Markowicz-Piasecka M, Cieślak M, Królewska-Golińska K, Hikisz P, Kusz J, Małecka M, Budzisz E. Biological evaluation of 3-Benzylidenechromanones and their spiropyrazolines-based analogues. Molecules, 2020, 25(7), 1613. doi: 10.3390/molecules25071613
  14. Naparło K, Soszyński M, Bartosz G, Sadowska-Bartosz I. Comparison of antioxidants: The limited correlation between various assays of antioxidant activity. Molecules, 2020, 25(14), 3244.
  15. Pietrasik S, Zajac G, Morawiec J, Soszynski M, Fila M, Blasiak J. Interplay between BRCA1 and GADD45A and its potential for nucleotide excision repair in breast cancer pathogenesis. International Journal of Molecular Sciences, 2020, 21(3), 870.
  16. Naparlo K, Bartosz G, Stefaniuk I, Soszynski M, Sadowska-Bartosz I. Interaction of catechins with human erythrocytes. Molecules, 2020, 25(6), 1456.
  17. Grebowski J, Konopko A, Krokosz A, DiLabio GA, Litwinienko G. Antioxidant activity of highly hydroxylated fullerene C60 and its interactions with the analogue of α-tocopherol. Free Radic Biol Med. 2020, 160, 734–744.
  18. Pichla M, Pulaski L, Kania KD, Stefaniuk I, Cieniek B, Pienkowska N, Bartosz G, Sadowska-Bartosz I. (2020) Nitroxide radicals-containing redox nanoparticles protect neuroblastoma SH-SY5Y cells against 6-hydroxydopamine toxicity. Oxidative Medicine and Cellular Longevity, 2020: 9260748.
  19. Grzela DP, Marciniak B, Pulaski L. Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome. Stem Cell Research, 2020, 46, 101858.
  20. Studzian M, Dzialak P, Pulaski L, Hedstrand DM, Tomalia DA, Klajnert-Maculewicz B. Synthesis, Internalization and Visualization of N-(4-Carbomethoxy) Pyrrolidone Terminated PAMAM [G5:G3-TREN] Tecto(dendrimers) in Mammalian Cells. Molecules, 2020, 25(19): E4406.
  21. Morgan K, Bryans A, Brzeszczyński F, Samuel K, Treskes P, Brzeszczyńska J, Morley S, Nelson, Hayes P. Oxygen plasma-treated substrates and specific nanopattern promote early differentiation and function of HepaRG progenitor cells. Tissue Engineering Part A (forthcoming), 2020. doi: 10.1089/ten.tea.2019.0241
  22. Brzeszczyńska J, Brzeszczyński F, Samuel K, Morgan K, Morley SD, Plevris JN, Hayes PC. Validation of reference genes for gene expression studies by RT-qPCR in HepaRG cells during toxicity testing and disease modelling. Cells, 2020, 9(3), 770.

2019

  1. Wojtala M, Dąbek A, Rybaczek D, Śliwińska A, Świderska E, Słapek K, El-Osta A, Balcerczyk A. Silencing lysine-specific histone demethylase 1 (LSD1) causes increased HP1-positive chromatin, stimulation of DNA repair processes and dysregulation of proliferation by Chk1 phosphorylation in human endothelial cells. Cells, 2019, 8(10), E1212. doi: 10.3390/cells8101212
  2. Chriett S, Dąbek A, Wojtala M, Vidal H, Balcerczyk A, Pirola L. Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor and anti-inflammatory molecule. Scientific Reports, 2019 9(1), 742.
  3. Lichota A, Gwozdzinski L, Gwozdzinski K. Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. Eur J Med Chem, 2019, 176, 68–91. doi: 10.1016/j.ejmech.2019.04.075
  4. Mucha P, Hikisz P, Gwoździński K, Krajewska U, Leniart A, Budzisz E. Cytotoxic effect, generation of reactive oxygen/nitrogen species and electrochemical properties of Cu(ii) complexes in comparison to half-sandwich complexes of Ru(ii) with aminochromone derivatives. RSC Adv., 2019, 9, 31943–31952. doi: 10.1039/c9ra05971g
  5. Morgan K, Martucci N, Kozlowska A, Gamal W, Brzeszczynki F, Treskes P, Samuel K, Hayes P, Nelson L, Bagnaninchi P, Brzeszczyńska J, Plevris J. Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomed Pharmacother, 2019, 111, 1408-1416. doi: 10.1016/j.biopha.2019.01.020
  6. Gerszon J, Wojtala M, Michlewska S, Rodacka A. Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells. Journal of Functional Foods, 2019, 58, 180-188. doi:10.1016/j.jff.2019.05.002
  7. Buczkowski A, Tokarz P, Stepniak A, Lewkowski J, Rodacka A, Palecz B. Spectroscopic and calorimetric studies of interactions between mitoxantrone and cucurbituril Q7 in aqueous solutions. 2019, 290, 111190 (8 pp). doi.10.1016/j.molliq.2019.111190.
  8. Rodacka A, Strumillo J, Puchala M, Serafin E, Bartosz G. Comparison of protective properties of resveratrol and melatonin in the radiation inactivation and destruction of glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase. International Journal of Radiation Biology, 2019, 95(11), 1472-1483, doi.org/10.1080/09553002.2019.1642539
  9. Papadakis R, Deligkiozi I, Nowak KE. Study of the preferential solvation effects in binary solvent mixtures with the use of intensely solvatochromic azobenzene involving [2]rotaxane solutes. Journal of Molecular Liquids, 2019, 274, 715–723.
  10. Pulaski L, Jatczak-Pawlik I, Sobalska-Kwapis M, Strapagiel D, Bartosz G, Sadowska-Bartosz I. 3-bromopyruvate induces expression of antioxidant genes. Free Radical Research, 2019, 53 (2), 170–178.
  11. Pietrzak J, Płoszaj T, Pulaski L, Robaszkiewicz A. EP300-HDAC1-SWI/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages. Biochimica Biophysica Acta - Gene Regulatory Mechanisms, 2019, 1862(2), 198–208.
  12. Gorzkiewicz M, Deriu MA, Studzian M, Janaszewska A, Grasso G, Pulaski L, Appelhans D, Danani A, Klajnert-Maculewicz B. Fludarabine-Specific Molecular Interactions with Maltose-Modified Poly(propyleneimine) Dendrimer Enable Effective Cell Entry of the Active Drug Form: Comparison with Clofarabine. Biomacromolecules, 2019, 20(3), 1429–1442.
  13. Jarczak J, Grochowalski Ł, Marciniak B, Lach J, Słomka M, Sobalska-Kwapis M, Lorkiewicz W., Pulaski L, Strapagiel D. Mitochondrial DNA variability of the Polish population. European Journal of Human Genetics, 2019, 27(8): 1304–1314.
  14. Radzik T, Boczek T, Ferenc B, Studzian M, Pulaski L, Zylinska L. Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells. Biomed Research International, 2019: 9616248.
  15. Karwaciak I, Sałkowska A, Karaś K, Sobalska-Kwapis M, Walczak-Drzewiecka A, Pulaski L, Strapagiel D, Dastych J., Ratajewski M. SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib. Cancers (Basel), 2019, 11(5), E673.
  16. Borówka P, Pulaski L, Marciniak B, Borowska-Strugińska B, Dziadek J, Żądzińska E, Lorkiewicz W, Strapagiel D. Screening methods for detection of ancient Mycobacterium tuberculosis complex fingerprints in next-generation sequencing data derived from skeletal samples. Gigascience, 2019, 8(6), giz065.
  17. Studzian M, Pulaski L, Tomalia D.A, Klajnert-Maculewicz B. Non-Traditional Intrinsic Luminescence (NTIL): Dynamic Quenching Demonstrates the Presence of Two Distinct Fluorophore Types Associated with NTIL Behavior in Pyrrolidone-Terminated PAMAM Dendrimers. Journal of Physical Chemistry C, 2019, 123(29), 18007–18016.
  18. Rozanski M, Studzian M, Pulaski L. Direct measurement of kinetic parameters of ABCG2-dependent transport of natural flavonoids using a fluorogenic substrate. Journal of Pharmacology and Experimental Therapeutics, 2019, 371(2), 309–319.
  19. Morgan K, Martucci N, Kozlowska A, Gamal W, Brzeszczynki F, Treskes P, Samuel K, Hayes P, Nelson L, Bagnaninchi P, Brzeszczyńska J, Plevris J. Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomedicine & Pharmacotherapy, 2019, 111, 1408–1416.

2018

  1. Strycharz J, Świderska E, Wróblewski A, Podolska M, Czarny P, Szemraj J, Balcerczyk A, Drzewoski J, Kasznicki J, Śliwińska A. Hyperglycemia Affects miRNAs Expression Pattern during Adipogenesis of Human Visceral Adipocytes-Is Memorization Involved? Nutrients, 2018, 10(11), E1774.
  2. Pirola L, Ciesielski O, Balcerczyk A. The methylation status of the epigenome: its emerging role in the regulation of tumor angiogenesis and tumor growth, and potential for drug targeting. Cancers (Basel), 2018, 10(8), E268. doi: 10.3390/cancers10080268.
  3. Wojtala M, Macierzyńska-Piotrowska E, Rybaczek D, Pirola L, Balcerczyk A. Pharmacological and transcriptional inhibition of the histone G9a methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacological Research, 2018, 128, 252-263.
  4. Pieniazek A, Gwozdzinski L, Zbrog Z, Gwozdzinski K. Alterations in conformational state of albumin in plasma in chronic hemodialyzed patients. PLoS One, 2018, 13(3), e0192268. doi: 10.1371/journal.pone.0192268
  5. Pieniazek A, Gwozdzinski L, Hikisz P, Gwozdzinski K. Indoxyl Sulfate Generates Free Radicals, Decreases Antioxidant Defense, and Leads to Damage to Mononuclear Blood Cells. Chem Res Toxicol, 2018, 31(9), 869–875. doi: 10.1021/acs.chemrestox.8b00065
  6. Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C. Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia. J Cachexia Sarcopenia Muscle, 2018, 9(1), 93–105. doi: 0.1002/jcsm.12252
  7. Strumillo J, Nowak KE, Krokosz A, Rodacka A, Puchala M, Bartosz G. The role of resveratrol and melatonin in the nitric oxide and its oxidation products mediated functional and structural modifications of two glycolytic enzymes: GAPDH and LDH. Biochim Biophys Acta Gen Subj, 2018, 1862(4), 877–885. doi: 10.1016/j.bbagen.2017.12.017.
  8. Gerszon J, Rodacka A. Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weight compounds in counteracting its aggregation and nuclear translocation. Ageing Res Rev. 2018, 48, 21–31. doi: 10.1016/j.arr.2018.09.003
  9. Gerszon J, Serafin E, Buczkowski B, Michlewska S, Bielnicki JA, Rodacka A. Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase. PLoS One, 2018, 13(1), e0190656. doi: 10.1371/journal.pone.0190656
  10. Sowa P, Misiolek M, Pasinski B, Bartosz G, Soszyński M, Adamczyk-Sowa M, Sadowska-Bartosz I. Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study. BioMed Research International, 2018, 2018, 4340871.
  11. Kazmierska-Grebowska P, Kobrzycka A, Bocian R, Kowalczyk T, Krokosz A, Grebowski J. Fullerenol C60(OH)36 at relatively high concentrations impairs hippocampal theta oscillations (in vivo and in vitro) and triggers epilepsy (in vitro) – A dose response study. Exp Mol Pathol. 2018, 105(1), 98–109.
  12. Grebowski J, Kazmierska P, Litwinienko G, Lankoff A, Wolszczak M, Krokosz A. Fullerenol C60(OH)36 protects human erythrocyte membrane against high-energy electrons. Biochim Biophys Acta Biomembr. 2018, 1860(8), 1528–1536.
  13. Strumillo J, Nowak KE, Krokosz A, Puchala M, Bartosz G. The role of resveratrol and melatonin in the nitric oxide and its oxidation products mediated functional and structural modifications of two glycolytic enzymes: GAPDH and LDH. Biochimica et Biophysica Acta – General Subjects, 2018, 1862(4), 877–885.
  14. Popielarski M, Ponamarczuk H, Stasiak M, Michalec L, Bednarek R, Studzian M, Pulaski L, Swiatkowska M. The role of Protein Disulfide Isomerase and thiol bonds modifications in activation of integrin subunit alpha11. Biochemical and Biophysical Research Communications, 2018, 495(2), 1635–1641.
  15. Ponamarczuk H, Popielarski M, Stasiak M, Bednarek R, Studzian M, Pulaski L, Babinska A., Swiatkowska M. Contribution of activated beta3 integrin in the PDI release from endothelial cells. Frontiers in Bioscience – Landmark, 2018, 23, 1612–1627.
  16. Gorzkiewicz M, Jatczak-Pawlik I, Studzian M, Pulaski L, Appelhans D, Voit B, Klajnert-Maculewicz B. Glycodendrimer Nanocarriers for Direct Delivery of Fludarabine Triphosphate to Leukemic Cells: Improved Pharmacokinetics and Pharmacodynamics of Fludarabine. Biomacromolecules, 2018, 19(2), 531–543.
  17. Gorzkiewicz M, Sztandera K, Jatczak-Pawlik I, Zinke R, Appelhans D, Klajnert-Maculewicz B, Pulaski L. Terminal Sugar Moiety Determines Immunomodulatory Properties of Poly(propyleneimine) Glycodendrimers. Biomacromolecules, 2018, 19(5), 1562–1572.
  18. Gorzkiewicz M, Buczkowski A, Appelhans D, Voit B, Pulaski L, Palecz B, Klajnert-Maculewicz B. Poly(propyleneimine) glycodendrimers non-covalently bind ATP in a pH- and salt-dependent manner – model studies for adenosine analogue drug delivery. International Journal of Pharmaceutics, 2018, 544(1), 83–90.
  19. Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C. Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 2018, 9(1), 93–105.
  20. Brzeszczyńska J, Morgan K, Brzeszczynski F, Samuel K, Hayes P, Plevris J. Towards understanding the mechanisms of chlorpromazine-induced hepatic toxicity using a human HepaRG-based mode, S141. In: The International Liver Congress 2018 Abstract Book. Journal of Hepatology, 2018, 68(1), S1–S926.

 

Chapters in books

  1. “Nutritional Epigenomics” edited by BS Ferguson – Book chapter: “Histone acylation in the epigenomic regulation of insulin action and metabolic disease” – Balcerczyk A, Biesiekierska M, Vialichka V, Pirola L – 2019.
  2. “Handbook of Nutrition, Diet and Epigenetics" edited by VR Preedy and VB Patel – Book chapter: “Insulin action, insulin resistance and their link to histone acetylation” – Balcerczyk A, Chriett S, Pirola L – 2018, doi: 10.1007/978-3-319-31143-2_57-1.
  3. “CBRN Security Manager Handbook SE-CBRN-URE” – edited by M Bijak – Book chapter: “Methods of detecting biological materials” – Bijak M, Synowiec E, Grębowski J, Kołodzejczyk-Czepas J, Ponczek M – 2018 – ISBN 978-83-8142-184-3.

 

Themes of diploma theses (last 3 years)

Themes of doctor's thesis:

  1. The role of lysine-specific demethylase 1 in the regulation of the inflammatory response of vascular endothelial cells.
  2. The influence of β-hydroxybutyrate on the energy balance of vascular endothelial cells.
  3. Analysis of the epigenetic profile of modification of selected arginines of core histones and their consequences for other post-translational modifications and the functioning of the vascular endothelium.
  4. Investigation of the epigenetic and transcriptional profile of insulin-sensitive tissues exposed to pro-oxidative and pro-inflammatory hyperglycemia compared to exposure to physiological ketosis states.
  5. Neuroprotective properties of piceatannol in model biological systems.
  6. The influence of melatonin and resveratrol on the structural and functional changes of glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase induced by reactive oxygen and nitrogen species.
  7. The effect of stilbene derivatives and ionizing radiation on breast cancer cells.

 

Themes of master's theses:

  1. Influence of epigallocatechin gallate (EGCG) on angiogenic potential and selected epigenome parameters of vascular endothelial cells.
  2. Influence of bioactive compounds from the fruit of the Punica granatum pomegranate, ellagic acid and gallic acid on the regulation of the process of colon cancer cell migration.
  3. Histone methyltransferase Set7/9 as a potential regulator of the angiogenic potential of HMEC-1 microvascular endothelial cells.
  4. Evaluation of the action of quercetin and epigallocatechin gallate in inhibiting glyceraldehyde-3-phosphate dehydrogenase aggregation under oxidative stress.
  5. Neuroprotective properties of low molecular weight natural compounds in preventing the glyceraldehyde-3-phosphate dehydrogenase’s aggregation induced by the action of oxidative stress.
  6. The effect of stilbene derivatives on radiosensitivity of breast cancer cells.
  7. The influence of indoxyl sulfate on oxidative stress parameters on human’s erythrocytes.

 

Themes of bachelor’s theses:

  1. Low-carbohydrate diet – a new panacea in the treatment and prevention of cardiovascular diseases?
  2. Why is it worth drinking green tea? – epigenetic potential of epigallocatechin gallate.
  3. The effect of indoxyl sulphate on the parameters of oxidative stress in human erythrocytes.
  4. Impact of air pollution on the development of neurodegenerative diseases.
  5. Polyphenols in prevention and treatment of cancer.
  6. The role of compounds of plant origin in counteracting protein and peptide aggregation associated with neurodegenerative processes.
  7. Nitric oxide, its biological effects and physiological role in neurodegenerative diseases.

 


 

Cytometry Laboratory

The Head of Laboratory: Błażej Rychlik, Ph.D.

Address: 141/143 Pomorska Str., 90–236 Łódź, building D, room W24 (measuring part)
12/16 Banacha Str., 90–237 Łódź, building A, rooms 5.23–5.35 (laboratory part)
Tel: +48 42 635 41 00 (building D), +48 42 665 50 74 (building A)
e-mail:

 

Staff of Cytometry Laboratory:

Name Phone e-mail Building/
Room
Consultations

Błażej Rychlik, Ph.D.
(The Head of Laboratory)

+48 42
635 41 00
D/W24  

Agnieszka Grzelak, Ph.D.

+48 42
665 50 74 

A/5.35

 

Andrzej Błauż, Ph.D.

+48 42
635 41 00 

D/W24

 

Marcin Wachulec, M.Sc.

+48 42
635 41 00 

D/W24

 

Mariusz Żuberek, Ph.D.

+48 42
665 50 74 

A/5.35

 

 

Ph.D. Students:

Name Phone e-mail Building/
Room
Consultations

M.Sc. Martyna Gruchała

+48 42
665 50 74 

A/5.35

 

M.Sc. Patrycja Paciorek

+48 42
665 50 74 

A/5.35

 

M.Sc. Michał Rakowski

+48 42
665 50 74 

A/5.35

 

 

Publications (JCR, last 3 years):

  1. Łomzik, M., Hanif, M., Budniok, A., Błauż, A., Makal, A., Tchoń, D., Leśniewska, B., Tong, K., Movassaghi, S., Söhnel, T., Jamieson, S., Zafar, A., Reynisson, J., Rychlik, B., Hartinger, C., Plażuk, D. (2020): Metal-dependent cytotoxic and kinesin spindle protein inhibitory activity of Ru, Os, Rh and Ir half-sandwich complexes of ispinesib-derived ligands. Inorganic Chemistry (przyjęte do druku).
  2. Biancalana,L., Gruchała, M., Batchelor, L.K., Błauż, A., Monti, A., Pampaloni, G., Rychlik, B., Dyson, P.J., Marchetti, F. (2020): Conjugating Biotin to Ruthenium(II) Arene Units via Phosphine Ligand Functionalization. Eur. J. Inorg. Chem., 11-12: 1061–1072.
  3. Paciorek, P., Żuberek, M., Grzelak, A. (2020): Products of Lipid Peroxidation as a Factor in the Toxic Effect of Silver Nanoparticles. Materials (Basel), 13(11): 2460.
  4. Pieńkowska, N., Bartosz, G., Pichla, M., Grzesik-Pietrasiewicz, M., Gruchała, M., Sadowska-Bartosz, I. (2020): Effect of antioxidants on the H2O2-induced premature senescence of human fibroblasts. Aging-US, 12(20): 1910-1927.
  5. Dasari, R., Błauż, A., Medellin, D.C., Kassim, R.M., Viera, C., Santarosa, M., van der Westhuyzen, A.E., van Otterlo, W.A.L., Olivas, T., Yildiz, T., Betancourt, T., Shuster, C.B., Rogelj, S., Rychlik, B., Hudnall, T., Frolova, L.V., Kornienko, A. (2019): Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins. ChemMedChem, 14 (3): 322-333.
  6. Kruszewski, M., Sikorska, K., Męczyńska-Wielgosz, S., Grzelak, A., Sramkova, M., Gabelova, A., Kapka-Skrzypczak, L. (2019): Comet assay in neural cells as a tool to monitor DNA damage induced by chemical or physical factors relevant to environmental and occupational exposure. Mutat Res., 845: 402990.
  7. Olszowiec-Chlebna, M., Koniarek-Maniecka, A., Brzozowska, A., Błauż, A., Rychlik, B., Stelmach, I. (2019): Vitamin D inhibits pro-inflammatory cytokines in the airways of Cystic Fibrosis patients infected by Pseudomonas aeruginosa- pilot study. Running titles: Vitamin D inhibits cytokines in CF patients. Ital. J. Pediatr., 45(1): 41 – 48.
  8. Jerzyńska, J., Stelmach, W., Rychlik, B., Majak, P., Podlecka, D., Woicka-Kolejwa, K., Stelmach, I. (2018): Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis. Arch Med Sci., 14(1): 122-131.
  9. Grzelak, A., Wojewódzka, M., Męczynska-Wielgosz, S., Żuberek, M., Wojciechowska D., Kruszewski M. (2018): Crucial role of chelatable iron in silver nanoparticles induced DNA damage and cytotoxicity. Redox Biol., 15: 435-440.
  10. Żuberek, M., Stępkowski, T.M., Kruszewski, M., Grzelak, A. (2018): Exposure of human neurons to silver nanoparticles induces similar pattern of ABC transporters gene expression as differentiation: Study on proliferating and post-mitotic LUHMES cells. Mech Ageing Dev., 171:7-14.
  11. Żuberek, M., Grzelak, A. (2018): Nanoparticles-Caused Oxidative Imbalance. Adv Exp Med Biol., 1048: 85-98
  12. Żuberek, M., Paciorek, P., Bartosz, G., Grzelak, A. (2017): Silver nanoparticles can attenuate nitrative stress. Redox Biol., 11: 646-652.

 

Publications (others, last 3 years):

  1. Paciorek, P., Żuberek, M., Grzelak, A. (2020): Rola miRNA w rozwoju wybranych nowotworów - potencjalne zastosowanie w diagnostyce. Postępy Higieny i Medycyny Doświadczalnej, 2020 10.
  2. Porębski, S., Grzelak, A. (2020): Klucz do badania procesów komórkowych - białka reporterowe. Kosmos (przyjęte do druku).
  3. Rakowski, M., Grzelak, A. (2020): Nowe zagrożenie zawodowe i środowiskowe – nanoplastik. Medycyna Pracy, 71(6).

 

Chapters in books

  1. Kruszewski,M., Grzelak, A.: Nanoparticle toxicity and reactive species: an overview [in:] Toxicology: Oxidative Stress and Dietary Antioxidants, eds. V. Patel i V. Preedy, Academic Press 2020.
  2. Kruszewski, M., Grzelak, A., Kapka-Skrzypczak, L., Lankoff, A.M.: Nanotoksykologia [in:] Toksykologia. Tom 2. Toksykologia szczegółowa i stosowana, eds. K. Jurowski i W. Piekoszewski, PZWL 2020.
  3. Kruszewski, M., Grzelak, A.: Nanotoksykologia [in:] Toksykologia w zadaniach Część 2, eds. K. Jurowski i W. Piekoszewski, PZWL 2020.

 


 

BioBank Laboratory

The Head of Laboratory: Dominik Strapagiel, Ph.D.

Address: 14/16 Józefa Pilarskiego Str., 90-231 Łódź
Tel: +48 42 665 57 02
e-mail:

 

Name Phone e-mail Building/
Room
Consultations

Dominik Strapagiel, Ph.D.
(The Head of Laboratory)

+48 42
665 57 02
   

Katarzyna Janik-Superson, Ph.D.

+48 42
665 57 02

   

Justyna Jarczak, Ph.D.

+48 42
665 57 02

   

Michał Seweryn, Ph.D.

+48 42
665 57 02 
   

Monika Baranowska, M.Sc.

+48 42
665 57 02 
   

Maciej Chyb, M.Sc.

+48 42
665 57 02 
   

Agnieszka Dąbrowska, M.Eng.

+48 42
665 57 02 
   

Sylwia Dobrowolska, M.Eng.

+48 42
665 57 02 
   

Łukasz Grochowalski, M.Sc.

+48 42
665 57 02 
   

Renata Gruszka, M.Sc.

+48 42
665 57 02 
   

Justyna Karkus, M.Sc.

+48 42
665 57 02 
   

Jakub Lach, M.Sc.

+48 42
665 57 02 
   

Błażej Marciniak, M.Eng.

+48 42
665 57 02 
   

Joanna Michalska-Madej, M.Eng.

+48 42
665 57 02 
   

Joanna Mietlińska, M.Sc.

+48 42
665 57 02 
   

Michalina Mikłos-Rakowska, M.Sc.

+48 42
665 57 02 
   

Illia Shrubkovskyi, M.Sc.

+48 42
665 57 02 
   

Marcin Słomka, M.Sc.

+48 42
665 57 02 
   

Marta Sobalska-Kwapisz, M.Eng.

+48 42
665 57 02 
   

Klaudyna Królikowska, B.Sc.

+48 42
665 57 02 
   

Maria Urbanowicz, B.Sc.

+48 42
665 57 02 
   

Łukasz Gajdzis, B.Eng.

+48 42
665 57 02 
   

 

The Biobank Lab of the University of Lodz is a unique research unit, which was created in order to collect biomaterials of the human origin and related with them clinical/questionnaire data. The Biobank Lab possesses samples from population-based collections (including the biggest one in Poland, over 10-thousandth representation of the Polish population) and disease-related collections (breast cancer, pancreatic cancer, endometriosis). In research, the state-of-the-art genetic methods are used like microarrays (the only database in Poland of genetic polymorphisms from genotyping around 550 000 polymorhisms each of the 6000 donors), new generation sequencing (NGS) – whole exome sequencing, sequencing of bacterial and bacteriophage genomes and anthropological DNA samples from the fossil material. So far, long-term cooperation with several major scientific institutions and biotechnological companies was established. From 2014, the Biobank Lab is a leading center in BBMRI.PL Consortium, which currently forms the National Network of Biobanks, and the Biobank Lab plays there role of the main management of the IT service.

 

Patents:

  1. Caban M, Strapagiel D, Bartosz G, Stączek P, Ciesielska A, Gadzalski M, et al., inventors; Univeristy of Lodz, assignee. The method of identifying pathogenic fungus species contained in a sample taken from a patient. Poland patent P. 408 734. 2018.
  2. Strapagiel D, Slomka M, Majewska M, Janik K, Sobalska M, Bartosz G, inventors; University of Lodz, assignee. Method for determination of gender Poland patent P. 406 569. 2019.
  3. Strapagiel D, Slomka M, Majewska M, Janik K, Sobalska M, Bartosz G, inventors; University of Lodz, assignee. Method for determination of gender Poland patent P. 423 420. 2019

 

Research projects carried out by the BioBank Laboratory:

  1. BBMRI.pl – “Research Infrastructure for Biobanks and Biomolecular Resources BBMRI-ERIC” – Polish Ministry of Science and Higher Education no. DIR/WK/2017/01 (2017–2021). Project implementation period: 27.01.2017-31.12.2021. Project manager: Dominik Strapagiel.
  2. POPC – “Digital sharing of biomolecular and descriptive resources of Biobank and Department of Anthropology, University of Łódź – characteristics of populations living in present-day Poland through the ages. Information platform e-Czlowiek.pl”. Polish Ministry of Science and Higher Education no. DIR/WK/2017/01 (Operational Programme Digital Poland for 2014–2020) – POPC.02.03.01-00.0012/17. Project implementation period: 02.11.2017-31.10.2020. Project manager: Błażej Marciniak.
  3. Let's Bio-IT – development of professional, bioinformatic, language and entrepreneurial skills of students of the Faculty of Biology and Environmental Protection, University of Łódź”. Project no. POWR.03.01.00-00-K410/16-00 (2017–2019). Project implementation period: 02.01.2017-31.12.2019. Project manager: Dominik Strapagiel.
  4. The study of the importance of epigenetic processes in the pathogenesis of mastocytosis to find new therapeutic options. founded by Polpharma Scientific Foundation (2018–2021). Grant awarded to the Medical University of Gdańsk, Department of Allergology, Department of Pneumology and Allergology. The Biobank became a co-contractor of the grant. Project manager: Dominik Strapagiel.
  5. Pattern of age and gender-related variability in skeletal mineral density and frequency of osteoporotic fractures from the Neolithic to the modern era as a determinant of changes in the biological condition of human populations”. Project no. OPUS12 (NCN), 2016/23/B/NZ8/03145. Project implementation period: 2017–2021. Function – contractor.
  6. Ecology of freshwater reservoirs in the context of the impact of human activity and geographical region - environmental DNA and more - acronym ECOPOND”. Project financed by the competition „GRIEG-1”, Project no. UMO-2019/34/H/NZ8/00683. Project implementation period: 2020–2023. Function – task coordinator Dominik Strapagiel.
  7. Factors of Mycobacterium tuberculosis affecting the frequency of transmission of tuberculosis”. Project no. POPC.02.03.01-00-0097/19-00 UMO-2019/35/B/NZ7/00942. Project implementation period: 2020–2023. Function – task coordinator Dominik Strapagiel.
  8. Genomic map of Poland in open access - digitization of biomolecular resources of the Biobank laboratory of the University of Lodz”. Project no. POPC.02.03.01-00-0097/19-00. Project implementation period: 2020–2023. Function – task coordinator Dominik Strapagiel, financial supervision over the implementation of the project.

 

Publications (last 3 years):

2020

  1. Wawrocki S, Seweryn M, Kielnierowski G, Rudnicka W, Druszczynska M. IL-18 and related function proteins associated with tuberculosis severity and screening for active TB among patients with non-mycobacterial community-acquired pneumonia (CAP). Saudi Journal of Biological Sciences, 2020.
  2. Słomka M, Sobalska-Kwapis M, Korycka-Machała M, Dziadek J, Bartosz G, Strapagiel D. Comprehensive Analysis of ABCG2 Genetic Variation in the Polish Population and Its Inter-Population Comparison. Genes, 2020, 11(10), 1144, doi:10.3390/genes11101144.
  3. Samotij D, Nedoszytko B, Bartosińska J, Batycka-Baran A, Czajkowski R, Dobrucki IT, Dobrucki LW, Górecka-Sokołowska M, Janaszak-Jasienicka A, Krasowska D, Kalinowski L, Macieja-Stawczyk M, Nowicki RJ, Owczarczyk-Saczonek A, Płoska A, Purzycka-Bohdan D, Radulska A, Reszka E, Siekierzycka A, Słomiński A, Słomiński R, Sobalska-Kwapis M, Strapagiel D, Szczerkowska-Dobosz A, Szczęch J, Żmijewski M, Reich A. Pathogenesis of psoriasis in the "omic" era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances. Postepy Dermatologii i Alergologii, 2020, 37(2), 135–153, doi: 10.5114/ada.2020.94832.
  4. Sałkowska A, Karaś I, Walczak-Drzewiecka A, Krawczyk M, Sobalska-Kwapis M, Dastych J, Ratajewski M. Identification of novel molecular markers of human Th17 cells. Cells, 2020, 9, 1611, doi: 10.3390/cells9071611.
  5. Nedoszytko B, Sobalska-Kwapis M, Strapagiel D, Lange M, Górska A, Elberink JNGO, van Doormaal J, Słomka M, Kalinowski L, Gruchała-Niedoszytko M, Nowicki RJ, Valent P, Niedoszytko M. Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups. Int. J. Mol. Sci., 2020, 21, 5506.
  6. Nedoszytko B, Szczerkowska-Dobosz A, Stawczyk-Macieja M, Owczarczyk-Saczonek A, Reich A, Bartosińska J, Batycka-Baran A, Czajkowski R, Dobrucki IT, Dobrucki LW, Górecka-Sokołowska M, Janaszak-Jasiecka A, Kalinowski L, Krasowska D, Purzycka-Bohdan D, Radulska A, Reszka E, Samotij D, Sobalska-Kwapis M, Słominski A, Słominski R, Strapagiel D, Szczęch J, Żmijewski M, Nowicki RJ. Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis. Advances in Dermatology and Allergology, 2020, 3(37), doi: 10.5114/ada.2020.96243.
  7. Bialik P, Wysokinski D, Slomka M, Morawiec Z, Strapagiel D, Wozniak K. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme — case-control study in breast cancer. Exp. Oncol., 2020, 42, 2, doi: 10.32471/exp-oncology.2312-8852.vol-42-no-2.14739.
  8. Korycka-Machała M, Pawełczyk J, Borówka P, Dziadek B, Brzostek A, Kawka M, Bekier A, Rykowski S, Olejniczak AB, Strapagiel D, Witczak Z, Dziadek J. PPE51 is involved in the uptake of disaccharides by Mycobacterium tuberculosis. Cells, 2020, 9, 603.
  9. Pruszkowska-Przybylska P, Sitek A, Rosset I, Sobalska-Kwapis M, Słomka M, Strapagiel D, Żądzińska E, Morling N. Association of saliva 25(OH)D concentration with body composition and proportion among pre-pubertal and pubertal Polish children. American Journal of Human Biology, 2020, doi: 10.1002/ajhb.23397.
  10. Jagielski T, Borówka P, Bakuła Z, Lach J, Marciniak B, Brzostek A, Dziadek J, Dziurzyński M, Pennings L, van Ingen J, Žolnir-Dovč Z, Strapagiel D. Genomic insights into the Mycobacterium kansasii complex: An update. Front. Microbiol., 2020, doi: 10.3389/fmicb.2019.02918.

2019

  1. Jarczak J, Lach J, Borówka P, Gałka M, Bućko M, Marciniak B, Strapagiel D. BioSCOOP - Biobank Sample Communication Protocol. New approach for the transfer of information between biobanks. Database (Oxford), 2019, doi: 10.1093/database/baz105.
  2. Zawilak-Pawlik A, Zarzecka U, Żyła-Uklejewicz D, Lach J, Strapagiel D, Tegtmeyer N, Böhm M, Backert S, Skorko-Glonek J. Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations. Science Report, 2019, 9(1), doi: 10.1038/s41598-019-48030-6.
  3. Korycka-Machała M, Viljoen A, Pawełczyk J, Borówka P, Dziadek B, Gobis K, Brzostek A, Kawka MI, Blaise M, Strapagiel D, Kremer L, Dziadek J. 1H-benzo[d]imidazole derivatives affect MmpL3 in Mycobacterium tuberculosis. Antimicrob Agents Chemother., 2019, doi: 10.1128/AAC.00441-19.
  4. Borówka P, Pułaski Ł, Marciniak B, Borowska-Strugińska B, Dziadek J, Żądzińska E, Lorkiewicz W, Strapagiel D. Screening methods for detection of ancient Mycobacterium tuberculosis complex fingerprints in next-generation sequencing data derived from skeletal samples. GigaScience, 2019, 8(6), doi: 10.1093/gigascience/giz065.
  5. Brodzik K, Krysztopa-Grzybowska K, Polak M, Lach J, Strapagiel D, Zasada AA. Analysis of the Amino Acid Sequence Variation of the 67–72p Protein and the Structural Pili Proteins of Corynebacterium diphtheriae for their Suitability as Potential Vaccine Antigens. Polish Journal of Microbiology, 2019, 68(2), doi:10.33073/pjm-2019-025.
  6. Dobrowolska S, Michalska-Madej J, Słomka M, Sobalska-Kwapis M, Strapagiel D. Biobank Łódź® – population based biobank at the University of Łódź, Poland. European Journal of Translational and Clinical Medicine, 2019, 1, 85-95 doi: 10.31373/ejtcm/109495.
  7. Karwaciak I, Sałkowska A, Karaś K, Sobalska-Kwapis M, Walczak-Drzewiecka A, Pułaski Ł, Strapagiel D, Dastych J, Ratajewski M. SIRT2 contributes to the resistance of melanoma cells to the multikinase inhibitor Dasatinib. Cancers (Basel), 2019, 11(5), doi: 10.3390/cancers11050673.
  8. Lorkiewicz W, Mietlińska J, Karkus J, Kurek M, Borówka P, Stuss M, Sewerynek E, Plażuk D, Żądzińska E. Osteoporotic bone fractures and age-related bone loss in males inhabiting the Kujawy region in north-central Poland from the Neolithic to early modern times. Journal of Archaeological Science, 2019, 103, 16–25, doi.org/10.1016/j.jas.2019.01.005.
  9. Pruszkowska-Przybylska P, Sitek A, Rosset I, Żądzińska E, Sobalska-Kwapis M, Słomka M, Strapagiel D. The association between socioeconomic status, duration of breastfeeding, parental age and birth parameters with BMI, body fat and muscle mass among prepubertal children in Poland. Anthropol. Anz., 2019, doi: 10.1127/anthranz/2019/0955.
  10. Płociński P, Macios M., Houghton J, Niemiec E, Płocińska R, Brzostek A, Słomka M, Dziadek J, Young D, Dziembowski A. Proteomic and transcriptomic experiments reveal an essential role of RNA degradosome complexes in shaping the transcriptome of Mycobacterium tuberculosis. Nucleic Acids Research, 2019, doi: 10.1093/nar/gkz251.
  11. Jarczak J, Grochowalski Ł, Marciniak B, Lach J, Słomka M, Sobalska-Kwapis M, Lorkiewicz W, Pułaski Ł, Strapagiel D. Mitochondrial DNA variability of the Polish population. European Journal of Human Genetics, 2019, doi: 10.1038/s41431-019-0381-x.
  12. Reczyńska D, Witek B, Jarczak J, Czopowicz M, Mickiewicz M, Kaba J, Zwierzchowski L, Bagnicka E. The impact of organic vs. inorganic selenium on dairy goat productivity and expression of selected genes in milk somatic cells. Journal of Dairy Research, 2019, 86(1), 48–54, doi: 10.1017/S0022029919000037.
  13. Karaś K, Sałkowska A, Sobalska-Kwapis M, Walczak-Drzewiecka A, Strapagiel D, Dastych J, Bachorz RA, Ratajewski M. Digoxin, an overlooked agonist of RORγ/RORγT. Front Pharmacol., 2019, 9, 1460, doi: 10.3389/fphar.2018.01460.
  14. Pułaski Ł, Jatczak-Pawlik I, Sobalska-Kwapis M, Strapagiel D, Bartosz G, Sadowska-Bartosz I. 3-Bromopyruvate induces expression of antioxidant genes. Free Radic. Biol. Med., 2019, 120, S111, doi: 10.1016/j.freeradbiomed.2018.04.367.

2018

  1. Fernandes DM, Strapagiel D, Borówka P, Marciniak B, Żądzińska E, Sirak K, Siska V, Grygiel R, Carlsson J, Manica A, Lorkiewicz W, Pinhasi R. A genomic Neolithic time transect of hunter-farmer admixture in central Poland. Sci. Rep., 2018, 8, 14879, doi: 10.1038/s41598-018-33067-w.
  2. Antczak M, Płocińska R, Płociński P, Rumijowska-Galewicz A, Żaczek A, Strapagiel D, Dziadek J. The NnaR orphan response regulator is essential for the utilization of nitrate and nitrite as sole nitrogen sources in mycobacteria. Sci Rep., 2018, 8(1), 17552, doi: 10.1038/s41598-018-35844-z.
  3. Lewczuk P, Gaignaux A, Kofanova O, Ermann N, Betsou F, Brandner S, Mroczko B, Blennow K, Strapagiel D, Paciotti S, Vogelgsang J, Roehrl MH, Mendoza S, Kornhuber J, Teunissen C. Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer's disease. Alzheimers Res. Ther., 2018, 10(1), 87, doi: 10.1186/s13195-018-0418-3.
  4. Pruszkowska-Przybylska P, Sitek A, Rosset I, Sobalska-Kwapis M, Słomka M, Strapagiel D, Żądzińska E. Association of the 2D:4D digit ratio with body composition among the Polish children aged 6–13 years. Early Human Development, 2018, 124, doi: 10.1016/j.earlhumdev.2018.08.001.
  5. Kukla-Bartoszek M, Pośpiech E, Spólnicka M, Karłowska-Pik J, Strapagiel D, Żądzińska E, Rosset I, Sobalska-Kwapis M, Słomka M, Walsh S, Kayser M, Sitek A, Branicki W. Investigating the impact of age-depended hair colour darkening during childhood on DNA-based hair colour prediction with the HIrisPlex system. Forensic Science International: Genetics, 2018, 36, 26–33, doi: 10.1016/j.fsigen.2018.06.007.
  6. Kozera Ł, Strapagiel D, Gleńska-Olender J, Chrościcka A, Ferdyn K, Skokowski J, Kalinowski L, Pawlikowski J, Marciniak B, Pasterk M, Matera-Witkiewicz A, Lewandowska-Szumiel M, Piast M, Witoń M. Biobankowanie ludzkiego materiału biologicznego dla celów naukowych w Polsce i Europie. Studia Iuridica LXXII, 2018, T.73, wyd. WUW, doi: 10.5604/01.3001.0012.1357.
  7. Marciniak B, Topolski P, Strapagiel D. Anonimizacja w dobie wielkich danych – sytuacja biobanków w kontekście RODO. Studia Iuridica LXXII, 2018, T.73, wyd. WUW, doi: 10.5604/01.3001.0012.1365.
  8. Bakuła Z, Brzostek A, Borówka P, Żaczek A, Szulc-Kielbik I, Podpora A, Parniewski P, Strapagiel D, Dziadek J, Proboszcz M, Bielecki J, van Ingen J, Jagielski T. Molecular typing of Mycobacterium kansasii using pulsed-field gel electrophoresis and a newly designed variable-nuber tandem repeat analysis. Sci. Rep., 2018, doi: 10.1038/s41598-018-21562-z.
  9. Holub P, Kohlmayer F, Prasser F, Mayrhofer MT, Schlunder I, Martin GM, Casati S, Koumakis L, Wutte A, Kozera L, Strapagiel D, Anton G, Zanetti G, Sezerman OU, Mendy M, Valik D, Lavitrano M, Dagher G, Zatloukal K, van Ommen GJB, Litton J-E. Enhancing reuse of data and biological material in medical research: from FAIR to FAIR-Health. Biopreservation and Biobanking, 2018, doi: 10.1089/bio.0110.

 

Master's theses topics:

Prace magisterskie:

  1. Study of Y-chromosome genetic variability of Polish Population using Infinium GSA genotyping array