prof. dr hab. Barbara Wachowicz PDF Drukuj Email
Stanowisko:
profesor emerytowany

Kontakt:
e-mail: wachbar(at)biol.uni.lodz.pl
tel. +48 (0) 42 635 44 85

Konsultacje:
pn.    12:00 – 13:00

Dydaktyka:
Biochemia II rok

Badania:
Badanie molekularnych mechanizmów aktywacji płytek krwi (adhezja, agregacja, sekrecja) ze szczególnym uwzględnieniem roli wolnych rodników i reaktywnych form tlenu; badanie wpływu endotoksyn i składników diety (witaminy: E, C, resweratrol, związki selenu) na metabolizm i funkcje płytek krwi.

 

Nota biograficzna:

Uzyskała tytuł magistra biochemii i stopień doktora i doktora habilitowanego na Uniwersytecie Łódzkim odpowiednio w 1965, 1972 i 1990 roku. Od 1965 roku pracuje na Uniwersytecie Łodzkim. Nominację profesorską z rąk prezydenta RP otrzymała w 1998 roku. Obecnie Kierownik Katedry Biochemii Ogólnej Uniwersytetu Łódzkiego. W 1970 roku stypendystka Uniwerstetu Schillera (Niemcy) w latach 1973-74 na Uniwersytecie w Oslo, w 1975 r. na Uniwersytecie Cambridge, a w 1980, 1982 i 1986 roku w King's College w Londynie.  Była prodziekan, Wydziału Biologii i Nauk o Ziemi (1990-1993). Była redaktor naczelny Acta Universitatis Lodziensis, Folia Biochimica et Biophisica.

Publikacje:

2010 rok

 

Effects of polyphenol-rich extract from berries of Aronia melanocarpa on the markers of oxidative stress and blood platelet activation. Platelets, vol. 21, no. 4, pp. 274–281, 2010

The lipid peroxidation in breast cancer patients. General Physiology and Biophysics, vol. 29, no. 2, pp. 208–210, 2010

Response of blood platelets to β-glucan from Saccharomyces cerevisiae. Platelets, vol. 21, no. 1, pp. 37–43, 2010

l-carnitine modulates blood platelet oxidative stress. Cell Biology and Toxicology, pp. 1–11, 2010

Effect of aronia on thiol levels in plasma of breast cancer patients. Central European Journal of Biology, vol. 5, no. 1, pp. 38–46, 2010

 

2009 rok

Dysfunction of fibrinolysis as a risk factor of thrombosis | Zaburzenia fibry no lizy jako czynnik ryzyka zakrzepicy. Polski Merkuriusz Lekarski, vol. 27, no. 160, pp. 341–345, 2009

Modification of human blood platelet proteins induced by homocysteine and its thiolactone in vitro. Thrombosis Research, vol. 124, no. 6, pp. 689–694, 2009

An extract from berries of aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patients. Planta Medica, vol. 75, no. 13, pp. 1405–1409, 2009

Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets, vol. 20, no. 7, pp. 487–492, 2009

Oxidative/nitrative modification of blood platelet proteins induced by thrombin in vitro. Thrombosis Research, vol. 123, no. 5, pp. 758–762, 2009

 

2008 rok

Studies on antioxidant properties of polyphenol-rich extract from berries of Aronia melanocarpa in blood platelets. Journal of Physiology and Pharmacology, vol. 59, no. 4, pp. 823–835, 2008

Apoptotic markers in human blood platelets treated with peroxynitrite. Platelets, vol. 19, no. 8, pp. 624–635, 2008

Comparative studies on homocysteine and its metabolite - homocysteine thiolactone action in blood platelets in vitro. Platelets, vol. 19, no. 7, pp. 520–527, 2008

Comparative studies of the antioxidant effects of a naturally occurring resveratrol analogue - Trans-3,3′,5,5′-tetrahydroxy-4′- methoxystilbene and resveratrol - Against oxidation and nitration of biomolecules in blood platelets. Cell Biology and Toxicology, vol. 24, no. 4, pp. 331–340, 2008

Protective effects of d-glucaro-1,4-lactone against oxidative modifications in blood platelets. Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 6, pp. 422–428, 2008

D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets. Cell Biology and Toxicology, vol. 24, no. 2, pp. 189–199, 2008

The effects of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen
General Physiology and Biophysics, vol. 27, no. 1, pp. 55–58, 2008

Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: Berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets, vol. 19, no. 1, pp. 70–77, 2008

 

2007 rok

Role of reactive nitrogen species in blood platelet functions. Platelets 18 (8) pp. 555–565

Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: Functional consequences. Thrombosis Research 121 (2), pp. 163–174

The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of γ-irradiation. Blood Coagulation and Fibrinolysis 18 (7), pp. 669-676

Haemostatic properties of human plasma subjected to a sterilizing dose of gamma irradiation in the presence of ascorbate. Blood Coagulation and Fibrinolysis 18 (3), pp. 271-277

Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins. Nutrition 23 (2), pp. 164-171

The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. Current Microbiology 54 (1), pp. 27-30

 

2006 rok

Antioxidant properties of trans-3,3′,5,5′-tetrahydroxy-4′-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compounds. Nutrition 22 (11-12), pp. 1202-1209

The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids. Cellular and Molecular Biology Letters 11 (1), pp. 1-11

Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro.  Platelets 17 (6), pp. 354-360

Novel selenoorganic compounds as modulators of oxidative stress in blood platelets. Cell Biology and Toxicology 22 (5), pp. 323-329

Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets. General Physiology and Biophysics 25 (2), pp. 215-222

Protein modification caused by a high dose of gamma irradiation in cryo-sterilized plasma: Protective effects of ascorbate. Free Radical Biology and Medicine 40 (3), pp. 536-542

Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite. Journal of Nutritional Biochemistry 17 (2), pp. 96-102

 

2005 rok

Interaction of reactive oxygen and nitrogen species with proteins | [Oddziaływanie reaktywnych form tlenu i azotu z białkami.] Postepy biochemii. 51 (2), pp. 140-145

The proinflammatory activity of lipopolysaccharide | [Aktywność prozapalna lipopolisacharydu.]. Postepy biochemii. 51 (3), pp. 280-287

Effects of lipopolysaccharides from gram-negative bacteria on the level of thiols in blood platelets. Current Microbiology 51 (3), pp. 153-155

Resveratrol inhibits polyphosphoinositide metabolism in activated platelets. Biochimica et Biophysica Acta - Biomembranes 1714 (2), pp. 125-133

Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets 16 (5), pp. 251-260

Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Anti-Cancer Drugs 16 (6), pp. 659-665

The effect of resveratrol on peroxynitrite-induced oxidation of proteins in blood platelets. Ukrainskii Biokhimicheskii Zhurnal 77 (2), pp. 215 
   
The effects of organoselenium compounds on blood platelets. Ukrainskii Biokhimicheskii Zhurnal 77 (2), pp. 226

Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. Bark. Nutrition 21 (2), pp. 199-206

 

2004 rok

Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters 9 (4 A), pp. 577-587

Peroxynitrite and fibrinolytic system: The effect of peroxynitrite on plasmin activity. Molecular and Cellular Biochemistry 267 (1-2), pp. 141-146

Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics 23 (3), pp. 315-326

The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thrombosis Research 113 (6), pp. 399-406

The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. Journal of Physiology and Pharmacology 55 (2), pp. 467-476

 

2003 rok

Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera Roezl. Bark, B. Olas, B. Wachowicz, . A. Stochmal, W. Oleszek, Nutrition 2003, 19, 633-640

Peroxynitrite-induced changes of thiol groups in human blood platelets P. Nowak, B. Olas, E. Bald, R. Głowacki, B. Wachowicz, Platelets 2003, 14, 375-379

Proces sekrecji w płytkach krwi, T. Zieliński, B. Wachowicz Postępy Biochemii, 2003, 3

Rola reaktywnych form tlenu w płytkach krwi B. Olas, B. Wachowicz Postępy Biologii Komórki, 2003, 2, 325-337

2002 rok

Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. Bark B. Olas, B. Wachowicz, A. Stochmal, W. Oleszek, Platelets, 2002, 13, 167-173

Generation of reactive oxygen species in blood platelets, B. Wachowicz, B. Olas, H.M. Żbikowska, A. Buczyński, Platelets 2002, 13, 175-182

Resveratrol, and vitamin C as antioxidants in blood platelets, B. Olas, B. Wachowicz, Thromb. Res. 2002, 106, 143-148

Peroxynitritre - mediated modification of fibrinogen affects platelet aggregation and adhesion, P. Nowak, B. Wachowicz, Platelets 2002, 13, 293-299

Polysaccharide part of Proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen, T. Zieliński, B. Wachowicz, J. Saluk-Juszczak, W. Kaca, Platelets 2002, 13, 419-424

Role of reactive oxygen species in aggregation of blood platelets treated with cisplatin, B. Olas, B. Wachowicz, Exp. and Clin. Physiol. and Biochem 2002, 4, 29-35

2001 rok

The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin", B. Olas, B. Wachowicz, J. Szewczuk, J. Saluk-Juszczak, W. Kaca, Microbios, 2001, 105, 7-13

Studies on pig blood platelet responses to peroxynitrite action,, P. Nowak, B. Wachowicz, Platelets, 2001,12, 376-381

The effects of peroxynitrite on pig platelet lipid peroxidation and the secretory process induced by thrombin,, P. Nowak, B. Wachowicz, Cytobios, 2001, S2, 179-187

Antioxidant activity of resveratrol in endotoxin - stimulated blood platelets,, B. Olas, B. Wachowicz, J. Saluk-Juszczak, T. Zieliński, W. Kaca, A. Buczyński, Cell Biology and Toxicology 2001, 17, 117-125

Cancer procoagulant and blood platelet activation,, B. Olas, B. Wachowicz, W. P. Mielicki, Cancer Letters 2001, 169, 165-171

Role of phosphoinositide 3-kinase in adhesion of platelets to fibrinogen stimulated by cancer procoagulant,, B. Olas, B. Wachowicz, W. P. Mielicki, Platelets, 2001,12, 431-435

The generation of superoxide anion in blood platelets in response to different forms of Proteus mirabilis lipopolysaccharide: effects of staurosporin, wortmannin and indomethacin,, T. Zieliński, B. Wachowicz, J. Saluk-Juszczak, W. Kaca, Thrombosis Research 2001, 103, 149-155

Adhesion of thrombin-stimulated and unstimulated blood platelets to collagen in the presence of Proteus mirabilis lipopolysaccharides,, J. Saluk-Juszczak, B. Wachowicz, T. Zieliński, W. Kaca, Platelets, 2001,12,

Selenium compounds in environment; their effect on human health B. Wachowicz, H. M. Żbikowska , P. Nowak Cell.Biol.Mol.Lett. 2001, 6, 2A, 375-381

The influence of resveratrol and statins (atorvastatin, provastatin) on aggregability of blood platelets from hypercholesterolemic patients” H.M Żbikowska, P. Nowak, B. Olas, M. Koter, J. Chojnowska-Jezierska, M. Broncel, B. Wachowicz , Atherosclerosis 2001

Biologiczna aktywność resweratrolu,, B. Olas, B. Wachowicz, Post. Hig. Med. Dośw., 2001, 55, 1; 71-79

Ekspresja P-selektyny na powierzchni płytek krwi indukowana endotoksyną bakteryjną Proteus mirabilis , J. Saluk-Juszczak, P. Nowak, J. Golański, B. Wachowicz, W. Kaca, Folia Biochimica et Biophysica, 15, 2001, 13-19

Proces sekrecji płytek krwi wywołany promieniowaniem UVB , K. Bednarska, B. Wachowicz Folia Biochimica et Biophysica, 15, 2001, 67-72

 

Poprawiony: czwartek, 11 października 2012 10:28