Stanowisko: profesor emerytowany
Kontakt: e-mail: wachbar(at)biol.uni.lodz.pl tel. +48 (0) 42 635 44 85
Konsultacje: pn. 12:00 – 13:00
Dydaktyka: Biochemia II rok
Badania: Badanie molekularnych mechanizmów aktywacji płytek krwi (adhezja, agregacja, sekrecja) ze szczególnym uwzględnieniem roli wolnych rodników i reaktywnych form tlenu; badanie wpływu endotoksyn i składników diety (witaminy: E, C, resweratrol, związki selenu) na metabolizm i funkcje płytek krwi.
Nota biograficzna:
Uzyskała tytuł magistra biochemii i stopień doktora i doktora habilitowanego na Uniwersytecie Łódzkim odpowiednio w 1965, 1972 i 1990 roku. Od 1965 roku pracuje na Uniwersytecie Łodzkim. Nominację profesorską z rąk prezydenta RP otrzymała w 1998 roku. Obecnie Kierownik Katedry Biochemii Ogólnej Uniwersytetu Łódzkiego. W 1970 roku stypendystka Uniwerstetu Schillera (Niemcy) w latach 1973-74 na Uniwersytecie w Oslo, w 1975 r. na Uniwersytecie Cambridge, a w 1980, 1982 i 1986 roku w King's College w Londynie. Była prodziekan, Wydziału Biologii i Nauk o Ziemi (1990-1993). Była redaktor naczelny Acta Universitatis Lodziensis, Folia Biochimica et Biophisica.
Publikacje:
2010 rok
Effects of polyphenol-rich extract from berries of Aronia melanocarpa on the markers of oxidative stress and blood platelet activation. Platelets, vol. 21, no. 4, pp. 274–281, 2010
The lipid peroxidation in breast cancer patients. General Physiology and Biophysics, vol. 29, no. 2, pp. 208–210, 2010
Response of blood platelets to β-glucan from Saccharomyces cerevisiae. Platelets, vol. 21, no. 1, pp. 37–43, 2010
l-carnitine modulates blood platelet oxidative stress. Cell Biology and Toxicology, pp. 1–11, 2010
Effect of aronia on thiol levels in plasma of breast cancer patients. Central European Journal of Biology, vol. 5, no. 1, pp. 38–46, 2010
2009 rok
Dysfunction of fibrinolysis as a risk factor of thrombosis | Zaburzenia fibry no lizy jako czynnik ryzyka zakrzepicy. Polski Merkuriusz Lekarski, vol. 27, no. 160, pp. 341–345, 2009
Modification of human blood platelet proteins induced by homocysteine and its thiolactone in vitro. Thrombosis Research, vol. 124, no. 6, pp. 689–694, 2009
An extract from berries of aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patients. Planta Medica, vol. 75, no. 13, pp. 1405–1409, 2009
Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets, vol. 20, no. 7, pp. 487–492, 2009
Oxidative/nitrative modification of blood platelet proteins induced by thrombin in vitro. Thrombosis Research, vol. 123, no. 5, pp. 758–762, 2009
2008 rok
Studies on antioxidant properties of polyphenol-rich extract from berries of Aronia melanocarpa in blood platelets. Journal of Physiology and Pharmacology, vol. 59, no. 4, pp. 823–835, 2008
Apoptotic markers in human blood platelets treated with peroxynitrite. Platelets, vol. 19, no. 8, pp. 624–635, 2008
Comparative studies on homocysteine and its metabolite - homocysteine thiolactone action in blood platelets in vitro. Platelets, vol. 19, no. 7, pp. 520–527, 2008
Comparative studies of the antioxidant effects of a naturally occurring resveratrol analogue - Trans-3,3′,5,5′-tetrahydroxy-4′- methoxystilbene and resveratrol - Against oxidation and nitration of biomolecules in blood platelets. Cell Biology and Toxicology, vol. 24, no. 4, pp. 331–340, 2008
Protective effects of d-glucaro-1,4-lactone against oxidative modifications in blood platelets. Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 6, pp. 422–428, 2008
D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets. Cell Biology and Toxicology, vol. 24, no. 2, pp. 189–199, 2008
The effects of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen General Physiology and Biophysics, vol. 27, no. 1, pp. 55–58, 2008
Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: Berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets, vol. 19, no. 1, pp. 70–77, 2008
2007 rok
Role of reactive nitrogen species in blood platelet functions. Platelets 18 (8) pp. 555–565
Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: Functional consequences. Thrombosis Research 121 (2), pp. 163–174
The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of γ-irradiation. Blood Coagulation and Fibrinolysis 18 (7), pp. 669-676
Haemostatic properties of human plasma subjected to a sterilizing dose of gamma irradiation in the presence of ascorbate. Blood Coagulation and Fibrinolysis 18 (3), pp. 271-277
Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins. Nutrition 23 (2), pp. 164-171
The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. Current Microbiology 54 (1), pp. 27-30
2006 rok
Antioxidant properties of trans-3,3′,5,5′-tetrahydroxy-4′-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compounds. Nutrition 22 (11-12), pp. 1202-1209
The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids. Cellular and Molecular Biology Letters 11 (1), pp. 1-11
Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro. Platelets 17 (6), pp. 354-360
Novel selenoorganic compounds as modulators of oxidative stress in blood platelets. Cell Biology and Toxicology 22 (5), pp. 323-329
Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets. General Physiology and Biophysics 25 (2), pp. 215-222
Protein modification caused by a high dose of gamma irradiation in cryo-sterilized plasma: Protective effects of ascorbate. Free Radical Biology and Medicine 40 (3), pp. 536-542
Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite. Journal of Nutritional Biochemistry 17 (2), pp. 96-102
2005 rok
Interaction of reactive oxygen and nitrogen species with proteins | [Oddziaływanie reaktywnych form tlenu i azotu z białkami.] Postepy biochemii. 51 (2), pp. 140-145
The proinflammatory activity of lipopolysaccharide | [Aktywność prozapalna lipopolisacharydu.]. Postepy biochemii. 51 (3), pp. 280-287
Effects of lipopolysaccharides from gram-negative bacteria on the level of thiols in blood platelets. Current Microbiology 51 (3), pp. 153-155
Resveratrol inhibits polyphosphoinositide metabolism in activated platelets. Biochimica et Biophysica Acta - Biomembranes 1714 (2), pp. 125-133
Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets 16 (5), pp. 251-260
Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Anti-Cancer Drugs 16 (6), pp. 659-665
The effect of resveratrol on peroxynitrite-induced oxidation of proteins in blood platelets. Ukrainskii Biokhimicheskii Zhurnal 77 (2), pp. 215 The effects of organoselenium compounds on blood platelets. Ukrainskii Biokhimicheskii Zhurnal 77 (2), pp. 226
Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. Bark. Nutrition 21 (2), pp. 199-206
2004 rok
Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters 9 (4 A), pp. 577-587
Peroxynitrite and fibrinolytic system: The effect of peroxynitrite on plasmin activity. Molecular and Cellular Biochemistry 267 (1-2), pp. 141-146
Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics 23 (3), pp. 315-326
The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thrombosis Research 113 (6), pp. 399-406
The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. Journal of Physiology and Pharmacology 55 (2), pp. 467-476
2003 rok
Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera Roezl. Bark, B. Olas, B. Wachowicz, . A. Stochmal, W. Oleszek, Nutrition 2003, 19, 633-640
Peroxynitrite-induced changes of thiol groups in human blood platelets P. Nowak, B. Olas, E. Bald, R. Głowacki, B. Wachowicz, Platelets 2003, 14, 375-379
Proces sekrecji w płytkach krwi, T. Zieliński, B. Wachowicz Postępy Biochemii, 2003, 3
Rola reaktywnych form tlenu w płytkach krwi B. Olas, B. Wachowicz Postępy Biologii Komórki, 2003, 2, 325-337
2002 rok
Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. Bark B. Olas, B. Wachowicz, A. Stochmal, W. Oleszek, Platelets, 2002, 13, 167-173
Generation of reactive oxygen species in blood platelets, B. Wachowicz, B. Olas, H.M. Żbikowska, A. Buczyński, Platelets 2002, 13, 175-182
Resveratrol, and vitamin C as antioxidants in blood platelets, B. Olas, B. Wachowicz, Thromb. Res. 2002, 106, 143-148
Peroxynitritre - mediated modification of fibrinogen affects platelet aggregation and adhesion, P. Nowak, B. Wachowicz, Platelets 2002, 13, 293-299
Polysaccharide part of Proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen, T. Zieliński, B. Wachowicz, J. Saluk-Juszczak, W. Kaca, Platelets 2002, 13, 419-424
Role of reactive oxygen species in aggregation of blood platelets treated with cisplatin, B. Olas, B. Wachowicz, Exp. and Clin. Physiol. and Biochem 2002, 4, 29-35
2001 rok
The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin", B. Olas, B. Wachowicz, J. Szewczuk, J. Saluk-Juszczak, W. Kaca, Microbios, 2001, 105, 7-13
Studies on pig blood platelet responses to peroxynitrite action,, P. Nowak, B. Wachowicz, Platelets, 2001,12, 376-381
The effects of peroxynitrite on pig platelet lipid peroxidation and the secretory process induced by thrombin,, P. Nowak, B. Wachowicz, Cytobios, 2001, S2, 179-187
Antioxidant activity of resveratrol in endotoxin - stimulated blood platelets,, B. Olas, B. Wachowicz, J. Saluk-Juszczak, T. Zieliński, W. Kaca, A. Buczyński, Cell Biology and Toxicology 2001, 17, 117-125
Cancer procoagulant and blood platelet activation,, B. Olas, B. Wachowicz, W. P. Mielicki, Cancer Letters 2001, 169, 165-171
Role of phosphoinositide 3-kinase in adhesion of platelets to fibrinogen stimulated by cancer procoagulant,, B. Olas, B. Wachowicz, W. P. Mielicki, Platelets, 2001,12, 431-435
The generation of superoxide anion in blood platelets in response to different forms of Proteus mirabilis lipopolysaccharide: effects of staurosporin, wortmannin and indomethacin,, T. Zieliński, B. Wachowicz, J. Saluk-Juszczak, W. Kaca, Thrombosis Research 2001, 103, 149-155
Adhesion of thrombin-stimulated and unstimulated blood platelets to collagen in the presence of Proteus mirabilis lipopolysaccharides,, J. Saluk-Juszczak, B. Wachowicz, T. Zieliński, W. Kaca, Platelets, 2001,12,
Selenium compounds in environment; their effect on human health B. Wachowicz, H. M. Żbikowska , P. Nowak Cell.Biol.Mol.Lett. 2001, 6, 2A, 375-381
The influence of resveratrol and statins (atorvastatin, provastatin) on aggregability of blood platelets from hypercholesterolemic patients” H.M Żbikowska, P. Nowak, B. Olas, M. Koter, J. Chojnowska-Jezierska, M. Broncel, B. Wachowicz , Atherosclerosis 2001
Biologiczna aktywność resweratrolu,, B. Olas, B. Wachowicz, Post. Hig. Med. Dośw., 2001, 55, 1; 71-79
Ekspresja P-selektyny na powierzchni płytek krwi indukowana endotoksyną bakteryjną Proteus mirabilis , J. Saluk-Juszczak, P. Nowak, J. Golański, B. Wachowicz, W. Kaca, Folia Biochimica et Biophysica, 15, 2001, 13-19
Proces sekrecji płytek krwi wywołany promieniowaniem UVB , K. Bednarska, B. Wachowicz Folia Biochimica et Biophysica, 15, 2001, 67-72
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