DEPARTMENT OF GENERAL BIOCHEMISTRY

DEPARTMENT OF GENERAL BIOCHEMISTRY                                       POLISH

Head of the Department: dr hab. Paweł Nowak, Prof. Associate

Adress: Molecular Biology Building (Building D)

ul. Pomorska 141/143

90-236 Łódź

Poland

Tel: +48 42 635 44 83

Fax: +48 42 635 44 82

e-mail: biochogl(at)biol.uni.lodz.pl

WWW adress/link biol.uni.lodz.pl/biochogl

 

Employees:

Name & Surname

Telephone

e-mail

Building/room

Consultations

dr hab. Paweł Nowak, prof. nadzw.

(Kierownik Katedry)

42 635 44 85

pnowak(at)biol.uni.lodz.pl

D / Bch33

Th 11:00–12:30

dr hab. Beata Olas, prof. nadzw.

+48 42 665 58 08
!internal:95808

olasb(at)biol.uni.lodz.pl

D / Bch52

M 10:00–11:00

dr hab. Joanna Saluk, prof. nadzw.

+48 42 635 43 36

saluk(at)biol.uni.lodz.pl

D / Bch32

M 11:00–12:30

dr hab. Małgorzata Żbikowska, prof. nadzw.

+48 42 635 44 83

zbikow(at)biol.uni.lodz.pl

D / Bch30

W 12:15–13:45

dr Joanna Kołodziejczyk-Czepas, adiunkt

+ 48 42 635 44 83

 

joannak(at)biol.uni.lodz.pl

D / Bch31

F 12:00–13:30

dr Bogdan Kontek, adiunkt

+48 42 665 58 08

kontekb(at)biol.uni.lodz.pl

D / Bch52

M 11:00–12:30

dr hab. Michał Ponczek, adiunkt

+48 42 635 44 83

 

mponczek(at)biol.uni.lodz.pl

D / Bch31

F 12:00–13:30

dr Michał Bijak
adiunkt

 +48 42 635 44 82

mbijak(at)biol.uni.lodz.pl

D / Bch50

M 12:30-14:00

mgr Joanna Boisse

 

 

D / Bch40

 

 

Ph.D. Students:

Name & surname

Telephone

e-mail

Consultations

mgr Agnieszka Morel

 

 

T 12:00-13:30

mgr Magdalena Szejk

 426354482

 szejkm(at)biol.uni.lodz.pl T 15:15-16:45

mgr Małgorzata Tomczyńska

 426354482

                                             tm(at)biol.uni.lodz.pl          

 

mgr Justyna Matczak

 426354482

 jmatczak(at)biol.uni.lodz.pl

T 10:00-11:30

mgr Natalia Cichoń

 426354482

 ncichon(at)biol.uni.lodz.pl

M 10:00-11:30

mgr Kamila Czubak

 

 kamilaczubak(at)biol.uni.odz.pl

F 13:00-14:30

mgr Małgorzata Sieradzka

   msieradzka(at)biol.uni.lodz.pl W 11:00-12:30

mgr Bartłomiej Pasiński

    T 10:00-11:30

mgr Bernadetta Lis

  bernadetta.lis(at)biol.uni.lodz.pl W 11:00-12:30

mgr Weronika Adach

  weronika.adach(at)biol.uni.lodz.pl W 10:30-12:00

mgr Bartosz Skalski

  bartosz.skalski(at)biol.uni.lodz.pl W 10:00-11:30

 

Research topics: 

  • Blood coagulation and fibrinolysis, platelet activation, the importance of reactive oxygen and nitrogen species in the activation of platelets, the mechanism of action of peroxynitrite, hydrogen sulfide homocysteine ​​and hemostasis system

  • Action of the selected activators and inhibitors on the metabolism of hemostasis and hemostatic function of platelets and proteins hemostatic

    Mechanisms for blood coagulation protein modifications caused by reactive oxygen and nitrogen species

  • Protective role of antioxidants against reactive oxygen and nitrogen species in hemostatic system

    Biomarkers of oxidative stress in the process of hemostasis in some pathological states and the significance of various antioxidants

  • Evaluation of oxidative stress markers and pro- and anticoagulant balance of in some pathological conditions

  • Proteomics of platelets in the states of normal and pathological conditions

  • Molecular evolution of proteins of hemostasis, a bioinformatic analysis of the amino acid sequences and protein domains of hemostasis, based on a search of the sequenced genomes of vertebrates

  • Homology modeling and molecular dynamics of proteins of hemostasis

  • Docking of low molecular weight ligands in search of modulators of proteins of hemostasis

  • Possible use of ionizing radiation to inactivate pathogens in blood plasma proteins

  • Preparation of blood products intended for transfusion (erythrocytes, platelets), and bioterapeutics for the production of (plasma proteins) using ionizing radiation; radioprotectant role of antioxidants

  • Searching for new natural and synthetic antioxidants and mechanisms of their protective action on oxidative stress

  • Analysis of selected plant extracts as potential anticoagulants, antioxidants and antiplatelet compounds; their possible use in the prophylaxis and treatment of civilization diseases

  • Interaction of platelets with lipopolysaccharides

Current projects: 

The specific substances in Kalanchoe daigremontiana roots and their biological activity (National Science Centre,  project duration 2013-2015).

Secondary metabolites of Pulmonaria officinalis L. and their biological activity (National Science Centre; project duration 2014-2017)

Scientific cooperation:

Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Pulawy, Poland

Department of Surgical Oncology, Medical University of Lodz (Copernicus Memorial Hospital, Lodz)

Department of Pharmacognosy, Medical University of Lodz

Department of Cosmetology, Medical University of Lodz

Selected publications:

    1. Design, synthesis, X-ray structures of the new coumarin derivatives and perspectives of binding them to albumin and vitamin K epoxide reductase complex subunit 1.Kasperkiewicz K, Malecka M, Ponczek MB, Nowak P, Budzisz E. CRYSTAL GROWTH & DESIGN. (2016)  16: 456-466
    2. Peroxynitrite and fibrinolytic system - the effects of peroxynitrite on t-PA-induced plasmin activity. Kolodziejczyk-Czepas J, Ponczek MB, Nowak P. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. (2015)  81: 212-219
    3. Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X. Bijak M, Ponczek MB, Nowak P. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. (2014) 65:  129-135
    4. Protective effects of grape seed extract against oxidative and nitrative damage of plasma proteins. Bijak, Michal; Kolodziejczyk-Czepas, Joanna; Ponczek, Michal Blazej; et al. (2012) INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES  51: 183-187
    5. Irradiation dose-dependent oxidative changes in red blood cells for transfusion. Zbikowska, Halina Malgorzata; Antosik, Adam (2012) INTERNATIONAL JOURNAL OF RADIATION BIOLOGY  88: 654-660
    6. Protective effects of (-)-epicatechin against nitrative modifications of fibrinogen. Bijak, Michal; Nowak, Pawel; Borowiecka, Marta; et al. (2012) THROMBOSIS RESEARCH  130: 123-128
    7. Aronia melanocarpa extract suppresses the biotoxicity of homocysteine and its metabolite on the hemostatic activity of fibrinogen and plasma. Malinowska, Joanna; Babicz, Karolina; Olas, Beata; et al. (2012) NUTRITION  28: 793-7
    8. Evolution of Thrombin and Other Hemostatic Proteases by Survey of Protochordate, Hemichordate, and Echinoderm Genomes. Ponczek, Michal B.; Bijak, Michal Z.; Nowak, Pawel Z. (2012) JOURNAL OF MOLECULAR EVOLUTION  74: 319-331
    9. Effect of short-term cryostimulation on antioxidative status and its clinical applications in humans. Miller, Elzbieta; Markiewicz, Lukasz; Saluk, Joanna; et al. (2012) EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY  112: 1645-1652
    10. The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients. Dietrich-Muszalska, Anna; Malinowska, Joanna; Olas, Beata; et al. (2012) NEUROCHEMICAL RESEARCH  37: 1057-1062
    11. Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro. Kolodziejczyk-Czepas, Joanna; Talar, Beata; Nowak, Pawel; et al. (2012) INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES  50: 754-758
    12. Epicatechin Inhibits Human Plasma Lipid Peroxidation Caused by Haloperidol In Vitro. Dietrich-Muszalska, Anna; Kontek, Bogdan; Olas, Beata; et al. (2012) NEUROCHEMICAL RESEARCH  37: 557-562
    13. Role of reactive nitrogen species in blood platelet functions. Olas, Beata; Wachowicz, Barbara (2007) PLATELETS  18: 555-565 
    14. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Olas, Beata; Wachowicz, Barbara; Tomczak, Anna; et al. (2008) PLATELETS  19: 70-77 
    15. Oxidative/Nitrative Modifications of Plasma Proteins and Thiols from Patients with Schizophrenia. Dietrich-Muszalska, Anna; Olas, Beata; Glowacki, Rafal; et al. (2009) NEUROPSYCHOBIOLOGY  59: 1-7 
    16. Isoprostenes as indicators of oxidative stress in schizophrenia. Dietrich-Muszalska, Anna; Olas, Beata (2009) WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY  10: 27-33 
    17. Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: Functional consequences. Nowak, Pawel; Zbikowska, Halina M.; Ponczek, Michal; et al. (2007) THROMBOSIS RESEARCH  121: 163-174 
    18. Evolution of the contact phase of vertebrate blood coagulation. Ponczek, M. B.; Gailani, D.; Doolittle, R. F. (2008) JOURNAL OF THROMBOSIS AND HAEMOSTASIS  6: 1876-1883